Well
Id probably have to go with MGS4. Best graphics to date, best MG game to date (IMO), great game overall.
Im a HUGE GTA fan, but the more I think about it, the more GTA4 really was overhyped. I know GTA4 was missing "something", it just wasnt as much fun as San Andreas. Saints row 2 was WAY more enjoyable.
Prince of Persia is fun, but definitely not GOTY good, same with Dead Space.. Havent tried fallout. R2 WAS my choice for GOTY before I knew they took out coop story mode (and not to mention they really screwed up the splitscreen overall).
So MGS4 with runner up being R2
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