Many will recommend calibrating.
The thing I notice missing from the calbration discussions it how often.
Weekly?
Monthly?
Yearly?
When you think it needs it?
For the hell of it?
At what? $200? $300?
How often are most people going to want to drop $200 - $300?
Something to also remember, even if you get your set as perfectly calibrated by a professional as possible, some sources will still look - screwy.
Channel to channel on HD cable/Sat can have hues at different ends of the spectrum.
Discs are no exception.
One Blu-ray may look incredible, the next... not so much.
Your set may be spot-on, but no one can guarantee the source is.
You might find yourself changing the brighness/backlight setting, contrast, edge enhancement, color level, hue, ??? - because the source you are watching *RIGHT NOW* looks wrong.
Green haired blonde girl maybe?
A red car that looks like it was sprayed onto your screen with a spraycan?
Grey sky?
Blue grass?
Violet water?
If everything looks - not right, on all sources, ya might want to have it calibrated.
Right now, on most channels/discs/files/sources, *MY* new HDTV looks pretty damn close.
Grass is green, sky is blue, nothing is overly saturated with color, it isn't so freakin bright you need a welding mask to watch it.
The generic "setup" items on Sony and Pixar discs are pretty close.
Me, personnaly, I'm ok with how my set looks to me - right now.
I will probably get it calibrated if it ever starts getting hosed on all sources.