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Originally Posted by JamesG.
Tony Todd guest-starred as an FBI agent for two Season 3 episodes of "24".
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He also played Worf’s brother, an older Jake and a Hirogen soldier on Star Trek.
Jeffery Combs played a number of different characters on DS9.
William Shatner was on The Twilight Zone a few times playing different roles each time. There were quite a few other actors like that.
Michelle Forbes was a semi regular on TNG from a Season 5 as Ensign Ro but her first appearance on the show was in a season 4 episode playing a different character.
Still on Star Trek, Mark Leonard played a Romulan in Balance of Terror and later came back as Sarek.
James Cromwell played a character in TNG season 3 episode The Hunted and late played Zefram Cochrane in First Contact.
Carolyn Seymour played two different Romulan commanders on TNG (Contagion and Face of the Enemy)
Robert OReilly in episode Manhunt of TNG season 2 episode before returning as Gowron later on in the series.
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