Batman & Robin, Cutthroat Island, and The Marvels.
B&R had a sequel put on ice (couldn't resist) and names like Alicia Silverstone were never the same after.
Cutthroat Island killed the pirate movie until POTC, killed Carolco, and brought the down the careers of Harlin and Davis.
The Marvels being a sequel to a billion dollar grosser probably shouldn't have led to one of the biggest financial disasters of all time, but it did.
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