What do you guys think?

[bluearth]

I would research that water cooler a bit more, doesnt appear to be so great going by some amazon reviews. I use a Cool Master Hyper 212 Plus ($25) and I get 29-31c idle temps. Once while using 80% of the cores power I got mid 40sC and have not seen 50c yet though 100% may get me there. Downside to the 212 Plus is it may cover one of your 4 ram slots, it covered one of mine.

Your motherboard. It has HDMI out etc but if you have a video card thats extra features your paying for you wont be using

Try to find a motherboard that fits what you want out of the PC. Strip it down as much as possible while keeping key features like 16x PCI express slot, SLI/crossfire support if thats in your plans, support for future CPUs like IVY Bridge if thats coming out soon, and at least 16 GBs memory support to future proof yourself.

The motherboard you picked out looks fine outsude of the unnecessary HDMI and other outputs which may be forced on all high end boards, just be careful to not make the same mistake I made and buy a certain motherboard when there were cheaper AND more expensive motherboards that better suited my needs. Just research like crazy.

With such a large budget consider buying two 1 TB HDDs and running them in RAID

Im a noob take what I say somewhat lightly just giving advice after my recent build