do I toe in the mains for my situation

[rmm2112]

All -- I unfortunately have a setup where i can not sit directly centered in front of my screen (and as well as the center speaker). But my question is - should I still toe-in the mains toward the center listening area (which no one is there) or point them straight, which will actually make the cones face the listener more so then toed in?

Or is it one of those try both and see how it sounds to you?

thanks in advance